演讲题目

调神健脾针法治疗功能性肠病临床及效应机制研究

Clinical study and effect mechanism of mind-regulating and spleen strengthening needing technique on functional bowel disease.

演讲摘要

南京中医药大学首任校长承淡安教授于20世纪30年代创办澄江针灸学派。至今为止，澄江针灸学派在世界范围内已传承了四代。

消化系统疾病包括炎症性胃肠病、功能性胃肠病、肿瘤等。目前，消化系统疾病是针灸的优势之一。著名期刊已发表了针灸治疗消化系统疾病的文章，如慢性功能性便秘(IF：21.317)、功能性消化不良(IF： 10.171/IF：7.890)、术后恶心呕吐(IF：7.067)、术后肠梗阻(IF：17.373)、肠易激综合征(IF：7.091)等。

肠易激综合征(IBS)是一种功能性胃肠道疾病，以腹痛或不适为特征，并伴有粪便不规则，包括便秘型(IBS-C)、腹泻型(IBS-D)、混合型(IBS-M)和不稳定型(IBS-U)。世界上约9.2%的人口受IBS影响。目前对肠易激综合征的治疗包括改变生活方式、专门饮食、心理治疗和药物治疗。

针灸是一种有益的治疗IBS替代方法。目前，本团队的多中心随机对照试验(519名患者IBS-C/IBS-D)证明了调神健脾针法(百会、印堂，双侧天枢、足三里、上巨虚、三阴交、太冲)比聚乙二醇/匹维溴铵更有效的减轻了IBS的症状，且效果可持续12周。参与者未发生严重副作用。此外，调神健脾针法治疗IBS的调节机制如下：免疫因子TH1/TH2和MC活化-PAR2-CGRP，内脏高敏感BDNF，脑-肠轴5-HT、NPY、CGRP，肠动力SCF/c-kit通路，肠道微生物和静息态功能下的大脑神经活动。

Professor Chang Danan, the founding president of Nanjing University of Chinese Medicine, founded Chengjiang Acupuncture School in 1930s. It has been passed down for four generations worldwide.

Diseases of the digestive system include inflammatory gastroenteropathy, functional gastroenteropathy, tumors, and others. At present, digestive system diseases are one of the advantages of acupuncture and moxibustion. For example, famous journals have published articles on acupuncture treatment of digestive system diseases, such as chronic severe functional constipation (IF: 21.317), functional dyspepsia (IF: 10.171/IF: 7.890), postoperative nausea and vomiting (IF: 7.067), postoperative ileus (IF: 17.373), and irritable bowel syndrome (IF: 7.091).

Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by abdominal pain or discomfort that is associated with stool irregularities, including constipation-predominant IBS (IBS-C), diarrhea-predominant IBS (IBS-D), mixed IBS (IBS-M), and unsteady IBS (IBS-U). It is estimated to affect approximately 9.2% of the world’s population. The current management for IBS includes lifestyle modification, specialized diets, psychological treatment, and pharmacologic therapies.

Acupuncture is considered a beneficial alternative treatment for IBS. Our previous multicenter randomized controlled trial (519 patients of IBS-C and IBS-D) has proved that mind-regulating and spleen strengthening needing technique (GV20, GV29, LR3, ST36, SP6, ST25 and ST37) may be more effective than PEG 4000/pinaverium bromide in alleviating the symptoms of IBS, with its effects lasting up to 12 weeks. No participant experienced severe adverse effects. Moreover, the regulation mechanism of Mind-regulating and spleen strengthening needing technique for IBS as follows: the immune of TH1/TH2 and MC activation -PAR2-CGRP, the visceral high sensitive of BDNF, the brain-intestinal axis of 5-HT, NPY and CGRP, the intestinal dynamic of SCF/c – kit pathway, gut microbes, and the resting state functional of brain activity.

About Dr. Jianhua Sun

个人简介

孙建华，博士，南京中医药大学博士生导师，首批“江苏省中医药领军人才”培养对象，“江苏省六大高峰人才”培养对象，现任江苏省中医院针灸康复科主任中医师，中国针灸学会常务理事，江苏省针灸学会副会长兼临床分会主任委员，中国针灸学会减肥与美容专业委员会主任委员，中国针灸学会盆底功能障碍专业委员会副主任委员，江苏省康复医学会常务理事，国家自然基金项目评审专家。国家中医药管理局重点学科、重点临床专科，江苏省中医药管理局重点临床专科、中医药示范专科学科负责人及学术带头人，SCI和中文杂志审稿专家。

主持和参加各级课题50余项，其中国家自然基金3项，其他国家级课题10余项，部省级课题20余项；发表SCI论文10余篇，包括著名期刊《Mayo Clinic Proceedings》（IF:7.091)、《Annals of Internal Medicine》（IF:17.135)、《JAMA》（IF:44.405），中文核心期刊百余篇，出版编著5部，出版教材1部，申请专利7项。分别获得中国针灸学会科技进步和江苏省中医药科技进步奖的二等奖三等奖，中国中医科学院科技进步三等奖1项。

致力于功能性胃肠病、中风病、痛症针灸效应机制研究30余年，具有丰富的临床经验，认为“治神”是针灸疗效关键，提出调神健脾针法治疗肠易激综合征的针灸特色治疗方案。

Sun Jianhua, PhD. Professor of Nanjing University of Chinese Medicine, the first batch of “Jiangsu Province TCM Leading Talents” and “Six Peak Talents in Jiangsu Province” training objects, director of acupuncture and rehabilitation department, Jiangsu Hospital of Traditional Chinese Medicine, director of Chinese Society of Acupuncture and Moxibustion, vice president and clinical chairman of Jiangsu Province acupuncture and moxibustion association, chairman of Weight-loss and Beauty Professional Committee of Chinese Acupuncture and Moxibustion Society, vice chairman of pelvic floor dysfunction committee of Chinese Society of Acupuncture and Moxibustion, director of Jiangsu Rehabilitation Association, the principal and academic leader of the key clinical specialty and TCM demonstration specialty of the State Administration of Traditional Chinese Medicine, the editorial board member of SCI and Chinese journal, evaluation expert of National Natural Fund project.

Presided and participated in more than 50 projects, including 3 projects funded by the National Natural Science Foundation of China, more than 10 other national projects, and more than 20 ministerial and provincial projects; Published more than 10 SCI papers, including Mayo Clinic Proceedings, Annals of Internal Medicine, and JAMA; Moreover, published 100 Chinese core journals, 5 books, 1 textbook, and applied 7 patents; Won the second and third prize of Scientific and technological progress of Chinese Acupuncture and Moxibustion Society, and Jiangsu TCM Science and Technology Progress, and the second and third prize of China Academy of Chinese Medical Sciences science and Technology.

Dedicated to the study of acupuncture effect mechanism of functional gastroenteropathy, apoplexy and pain for more than 30 years. Has rich clinical experience and believes that “treating the mind” is the key to the curative effect of acupuncture and moxibustion, and proposes the treatment of mind-regulating and spleen strengthening needing technique for irritable bowel syndrome.